منابع مشابه
Mechanisms of Vascular Insulin Resistance
Insulin resistance is characterized by the diminished ability of insulin to initiate intracellular signaling. It is a common manifestation of obesity and a prelude to type 2 diabetes. The primary targets of insulin are skeletal muscle, adipose, and the liver. Impaired insulin signaling in these tissues reduces glucose uptake and promotes a metabolic syndrome that is characterized by elevated le...
متن کاملNuclear FoxO1 inflames insulin resistance.
Chronic activation of macrophage-mediated inflammatory signals in insulin-sensitive metabolic tissues is thought to be one of the causes of insulin resistance—one of the hallmarks of the metabolic syndrome. However, the mechanisms, components and dynamics by which this inflammatory response is spatially and temporally regulated are not completely understood. In this issue of The EMBO Journal, O...
متن کامل[Molecular Mechanisms of Insulin Resistance: An Update].
The biological actions of insulin are initiated by activating its membrane receptor, which triggers multiple signaling pathways to mediate their biological actions. Due to the importance of metabolic regulation and promoting functions of cell growth and proliferation, insulin actions are highly regulated to promote proper metabolic functioning and energy balance. If these mechanisms are altered...
متن کاملMechanisms of insulin resistance in cystic fibrosis.
Cystic fibrosis (CF) is associated with a high incidence of diabetes. Studies evaluating causes of CF-related diabetes (CFRD) have consistently documented decreased insulin secretion. In patients with CFRD, insulin sensitivity has been documented to be decreased, but controversy exists in patients with normal or impaired glucose tolerance (IGT). We undertook this study 1) to reexplore insulin s...
متن کاملMechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization.
Cellular and tissue defects associated with insulin resistance are coincident with transcriptional abnormalities and are improved after insulin sensitization with thiazolidinedione (TZD) PPARgamma ligands. We characterized 72 human subjects by relating their clinical phenotypes with functional pathway alterations. We transcriptionally profiled 364 biopsies harvested before and after hyperinsuli...
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ژورنال
عنوان ژورنال: Trends in Cell Biology
سال: 2016
ISSN: 0962-8924
DOI: 10.1016/j.tcb.2016.01.002